Dr. Zucai Suo

Dr. Zucai Suo
Stem Field
Biomedical Sciences
Title of Research
Development of exosome-based therapies for treating cancer and CNS diseases
Description of Research Area

Exosomes are membranous vesicles with a diameter range of 30-200 nm that are released extracellularly by almost all cell types to aid intercellular communication. Exosomes are complex entities that carry a multitude of signaling moieties, such as proteins, lipids, cell surface receptors, enzymes, cytokines, transcription factors, amino acids, metabolites, and nucleic acids. A growing body of evidence suggests that in addition to delivering various cargos into target cells, exosomes also play important roles in such diverse processes as cell differentiation and proliferation, angiogenesis, stress response, and immune signaling. Their favorable biological properties such as biocompatibility, stability in circulation, low toxicity, low immunogenicity, and efficient exchange of molecular cargos make them ideal candidates for tissue engineering and regenerative medicine as well as drug delivery vehicles. Exploring and identifying their functions and molecular payloads can facilitate drug development to treat many human diseases including cancer, CNS disorders, wound healing, etc. The Suo lab has been working on drug discovery by using extracellular vehicles including exosomes. Any interested postdoctoral candidates are encouraged to apply to the Suo lab to work on exosome-based drug development projects. There is a possibility that you could co-found a biotech company with your colleagues based on your research in the Suo lab.

Special Research & Career Skills

A qualified postdoc candidate should have a PhD in cell biology, molecular biology, neurobiology, biochemistry, or pharmaceutical sciences. Background and experience in cell-based assays, confocal microscopy, TIRF, TEM, animal models, Mesenchymal stem cells, extracellular vehicles, immunofluoresence, Western-blot, protein purification, subcloning, high throughput drug screening assays, and/or nucleic acids are preferred.