We have a diverse lab largely focused on identification and amelioration of causal risk factors for psychopathology. The primary forms of psychopathology include anxiety and related conditions such as OC-spectrum conditions as well as addictive behaviors (smoking, cannabis). In addition, a more recent focus has been on suicidal behavior and gun violence. Our laboratory uses a range of techniques that includes EEG, hormonal and genetic analyses. We also utilize biological and behavioral stress paradigms including CO2 challenge, shooting simulation, and virtual reality. In recent years, our interventions have focused on the use of brief, cognitive behavioral and cognitive bias modification paradigms primarily delivered using technology such as web applications. At this point, we have developed close to a dozen different interventions focused on risk constructs such as anxiety sensitivity, intolerance of uncertainty, perceived burdensomeness, and thwarted belongingness.