My laboratory is interested in the organization and maintenance of chromatin at the human inactive X chromosome. We use cutting edge genome engineering approaches as well as molecular genomic techniques (high throughout and non-high throughput, including qPCR, RNA-Seq and ChIP-Seq), fluorescence microscopy and cell biology to address fundamental questions related to epigenetics and chromatin biology.

Current projects focus on: (A) Investigating the roles of specific DNA sequences on the X chromosome and how they are epigenetically regulated to perform important roles in maintaining the 3-dimensional (3D) and heterochromatin organization of the human inactive X chromosome (Xi), and (B) investigating the role of long noncoding RNAs and heterochromatin proteins in maintaining the transcriptional state and the 3D and chromatin organization of the Xi.